The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

Summary: p53 regulates multiple signaling pathways and maintains cell homeostasis under conditions of DNA damage and oxidative stress. Although USP7 has been shown to promote p53 stability via deubiquitination, the USP7-p53 activation mechanism has remained unclear. Here, we propose that DNA damage...

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Κύριοι συγγραφείς:	Jingwei Liu, Liangzi Cao, Yubang Wang, Yu Zou, Qiqiang Guo, Shu Chen, Bo Jiang, Xuan Wu, Lixia Zheng, Siyi Zhang, Songming Lu, Keshen Zhou, Pengcheng Jiang, Yutong Xiao, Ruohan Yang, Shiyuan Dong, Ziwei Li, Di Chen, Ying Zhang, Naijin Zhang, Guozhe Sun, Chengzhong Xing, Xiaoyu Song, Zhenning Wang, Liu Cao
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2024-06-01
Σειρά:	Cell Reports
Θέματα:	CP: Molecular biology
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2211124724006946
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