Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer

The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in complex autoimmune diseases. Altered expression of RCA g...

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Hlavní autoři:	Jessica Cheng, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Rhonda L. Taylor, Sündüz Keleş, Martin Franke, Susan A. Boackle, John B. Harley, Elizabeth Quail, José Luis Gómez-Skarmeta, Daniela Ulgiati
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-06-01
Edice:	Frontiers in Immunology
Témata:	RCA B cells enhancers chromatin looping TADs
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.901747/full
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