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Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque

The accurate germline gene assignment and assessment of somatic hypermutation in antibodies induced by immunization or infection are important in immunological studies. Here, we illustrate issues specific to the construction of comprehensive immunoglobulin (IG) germline gene reference databases for...

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Principais autores: Mateusz Kaduk, Martin Corcoran, Gunilla B. Karlsson Hedestam
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-03-01
Serier:Frontiers in Immunology
Fag:
antibody repertoire
next generation sequencing
macaques
immunoglobulin germline genes
structural variation
databases
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.818440/full
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