Human Microglia Extensively Reconstitute in Humanized-BLT Mice With Human Interleukin-34 Transgene and Support HIV-1 Brain Infection

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hematopoietic stem and progenitor cells (HSPCs) can enter the brain...

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Principais autores:	Jianshui Zhang, Saroj Chandra Lohani, Yilun Cheng, Tao Wang, Lili Guo, Woong-Ki Kim, Santhi Gorantla, Qingsheng Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Immunology
Assuntos:	microglia interleukin-34 NOG mice Hu-BLT mice HIV-1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.672415/full
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