Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity

Abstract The reduction of cellular PD-L1 abundance through lysosomal degradation is recognized as essential for effective and sustained targeting of PD-L1-dependent immune evasion in cancer. While Hsc70 can interact with PD-L1 to promote its lysosomal degradation, the overexpression of CMTM6 competi...

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Autors principals:	Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-02-01
Col·lecció:	Journal of Nanobiotechnology
Matèries:	Lysosomal degradation Cellular abundance of PD-L1 Peptide Supramolecule Tumor immunotherapy
Accés en línia:	https://doi.org/10.1186/s12951-025-03171-x
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