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Pharmacomodulations around an anti-Alzheimer drug-candidate

Alzheimer's disease is a complex and multifactorial disease characterized by extracellular Aβ peptide deposits related to the deregulation of APP metabolism, intracellular aggregation of hyper and abnormally phosphorylated isoforms of Tau proteins, cell death and neuroinflammation. Targeting all the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sylvain Marc, Christophe Mésangeau, Mathilde Coevoet, Amélie Barczyk, Stéphane Burlet, Philippe Verwaerde, Cecilia Estrella, Cyrille Brantis, Nicolas Sergeant, Pascal Carato, Patricia Melnyk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2022-04-01
Schriftenreihe:European Journal of Medicinal Chemistry Reports
Schlagworte:
Alzheimer's disease
Amyloid precursor protein
Benzimidazole
Piperazine
Drug candidate
Pharmacomodulation
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2772417421000200
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