Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo

Abstract Background Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity. This study aimed to investigate the deleterious effects of polystyrene na...

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Bibliografische Detailangaben

Hauptverfasser:	Yuji Huang, Boxuan Liang, Zhiming Li, Yizhou Zhong, Bo Wang, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Weicui Min, Xiliang Yan, Yanhong Deng, Yu Feng, Ruobing Bai, Bingchi Fan, Xingfen Yang, Zhenlie Huang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-11-01
Schriftenreihe:	Particle and Fibre Toxicology
Schlagworte:	Microplastics and nanoplastics Mitophagy Mitochondrial dysfunction Complex I Neurotoxicity Melatonin
Online-Zugang:	https://doi.org/10.1186/s12989-023-00556-4
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