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Scalable screening of ternary-code DNA methylation dynamics associated with human traits

Summary: Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits. We introduce the methylation screening array (MSA) to enable scalable and quantitative screening of trait-associated DNA cytosine modifications in lar...

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Hoofdauteurs: David C. Goldberg, Cameron Cloud, Sol Moe Lee, Bret Barnes, Steven Gruber, Elliot Kim, Anita Pottekat, Maximillian S. Westphal, Luana McAuliffe, Elisa Majounie, Manesh Kalayil Manian, Qingdi Zhu, Christine Tran, Mark Hansen, Jelena Stojakovic, Jared B. Parker, Rahul M. Kohli, Rishi Porecha, Nicole Renke, Wanding Zhou
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-09-01
Reeks:Cell Genomics
Onderwerpen:
DNA methylation
epigenetics
epigenome-wide association study
5-hydroxymethylation
epigenetic clock
Infinium array
Online toegang:http://www.sciencedirect.com/science/article/pii/S2666979X25001855
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