Construction of pre-vascularized bone-like tissue by incorporation of mesodermal progenitor cells through simulating endochondral ossification

Abstract Background Pre-vascularized cartilage enhances bone regeneration (intrachondral osteogenesis) and accelerates bone defect healing. While current strategies focus on co-culturing chondrocytes with endothelial cells, mature endothelial cells inhibit the necessary osteogenic transformation. To...

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Detalles Bibliográficos

Principais autores:	Yian Guan, Zixin Wang, Hui Wang, Rong Huang, Jing Lin, Yuan Wang, Dongyang Ma, Ping Zhou, Liling Ren
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-05-01
Series:	Stem Cell Research & Therapy
Assuntos:	Chondrocytes Endochondral ossification Human pluripotent induced stem cells Mesodermal cells Vascularization
Acceso en liña:	https://doi.org/10.1186/s13287-026-05071-9
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