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The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension

Abstract Human WIPI β-propellers function as PI3P effectors in autophagy, with WIPI4 and WIPI3 being able to link autophagy control by AMPK and TORC1 to the formation of autophagosomes. WIPI1, instead, assists WIPI2 in efficiently recruiting the ATG16L1 complex at the nascent autophagosome, which in...

Deskribapen osoa

Gorde:
Egile Nagusiak: Katharina Sporbeck, Maximilian L. Haas, Carmen J. Pastor-Maldonado, David S. Schüssele, Catherine Hunter, Zsuzsanna Takacs, Ana L. Diogo de Oliveira, Mirita Franz-Wachtel, Chara Charsou, Simon G. Pfisterer, Andrea Gubas, Patricia K. Haller, Roland L. Knorr, Manuel Kaulich, Boris Macek, Eeva-Liisa Eskelinen, Anne Simonsen, Tassula Proikas-Cezanne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2023-08-01
Saila:Communications Biology
Sarrera elektronikoa:https://doi.org/10.1038/s42003-023-05236-9
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