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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions. Previous studies demonstrated dysregulation of some individual surfactant components in COPD. We investigated...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I. Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A. Wilkinson, on behalf of the MICA II Study group
التنسيق: Artigo
اللغة:Inglês
منشور في: European Respiratory Society 2022-05-01
سلاسل:ERJ Open Research
الوصول للمادة أونلاين:http://openres.ersjournals.com/content/9/3/00378-2022.full
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