The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients

Genome-wide association studies unveiled the associations between the single nucleotide polymorphism rs16969968 of CHRNA5, encoding the nicotinic acetylcholine receptor alpha5 subunit (α5SNP), and nicotine addiction, cancer, and COPD independently. Here, we investigated α5SNP-induced epithelial remo...

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Principais autores:	Lynda Saber Cherif, Zania Diabasana, Jeanne-Marie Perotin, Julien Ancel, Laure M. G. Petit, Maëva A. Devilliers, Arnaud Bonnomet, Nathalie Lalun, Gonzague Delepine, Uwe Maskos, Philippe Gosset, Myriam Polette, Anaëlle Muggeo, Thomas Guillard, Gaëtan Deslée, Valérian Dormoy
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-09-01
Series:	Cells
Assuntos:	COPD airways epithelial remodeling nicotinic receptors rs16969968 inflammation
Acceso en liña:	https://www.mdpi.com/2073-4409/11/19/2937
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