Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?

RNA viruses with pandemic potential pose a significant global health risk. The adenosine nucleoside analog GS-441524 is metabolized to its active GS-443902 triphosphate metabolite to inhibit a broad spectrum of RNA viruses. Intravenous (IV) remdesivir (RDV) and oral obeldesivir (ODV) are phosphorami...

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Principais autores:	Darius Babusis, Cynthia Kim, Jesse Yang, Xiaofeng Zhao, Guoju Geng, Carmen Ip, Nathan Kozon, Hoa Le, Jennifer Leung, Jared Pitts, Dustin S. Siegel, Rao Kalla, Bernard Murray, John P. Bilello, Roy Bannister, Richard L. Mackman, Raju Subramanian
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-06-01
Series:	Viruses
Assuntos:	pharmacokinetics remdesivir obeldesivir antivirals GS-441524 GS-443902
Acceso en liña:	https://www.mdpi.com/1999-4915/17/6/836
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