Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that a loss of LC neurons can enhance the susceptibility of dopaminergic neurons to damage. To det...

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Detaylı Bibliyografya
Asıl Yazarlar:	Patricia eSzot, Allyn eFranklin, Carl eSikkema, Charles W Wilkinson, Murray A Raskind
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2012-10-01
Seri Bilgileri:	Frontiers in Pharmacology
Konular:	Catecholamines Locus Coeruleus Substantia Nigra Ventral Tegmental Area Striatum 6-hydroxydopamine
Online Erişim:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00184/full
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Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

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