Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain

Abstract Background Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer’s disease (AD) has been reported; RIPK1 is involved in microglia’s phenotypic...

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Bibliografiske detaljer

Principais autores:	Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, Takafumi Minamimoto, Makoto Higuchi, Ming-Rong Zhang, Takashi Kato, Kengo Ito, Masaaki Suzuki, Yasuyuki Kimura
Format:	Artigo
Sprog:	Inglês
Udgivet:	SpringerOpen 2023-10-01
Serier:	EJNMMI Radiopharmacy and Chemistry
Fag:	Receptor interacting protein kinase 1 Alzheimer’s disease Positron emission tomography
Online adgang:	https://doi.org/10.1186/s41181-023-00217-z
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