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Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats

Zapnometinib is a MEK inhibitor currently under clinical development for the treatment of COVID-19 and influenza. Zapnometinib has both antiviral and immunomodulatory effects. Information concerning the absorption, distribution, metabolism, and excretion of the compound following single oral doses o...

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Principais autores: Yvonne Füll, Christian Wallasch, Ashley Hilton, Oliver Planz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-12-01
coleção:Frontiers in Pharmacology
Assuntos:
mek inhibitor
absorption
distribution
metabolism
excretion
antiviral therapy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.1050193/full
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