Preventive or promotive effects of PRNP polymorphic heterozygosity on the onset of prion disease

The polymorphic heterozygosity of PRNP at codon 129 or 219 prevents the onset of sporadic Creutzfeldt-Jakob disease (sCJD). We investigated the association between polymorphic genotypes at codon 129 or 219 and comprehensive prion disease onset using non-CJD as a reference. EK heterozygotes at codon...

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Hauptverfasser:	Hideaki Kai, Kenta Teruya, Atsuko Takeuchi, Yoshikazu Nakamura, Hidehiro Mizusawa, Masahito Yamada, Tetsuyuki Kitamoto
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-03-01
Schriftenreihe:	Heliyon
Schlagworte:	Creutzfeldt-jakob disease Prion PRNP Genetic prion disease Polymorphism Electrostatic interaction
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405844023011817
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