Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders

The human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) is the first member of the solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA transporters in the central nervous system. Its principal physiological role is retrieving GABA from the synapse into neurons and...

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Автори:	Florian P. Fischer, Ameya S. Kasture, Thomas Hummel, Sonja Sucic
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2022-03-01
Серія:	Frontiers in Molecular Biosciences
Предмети:	autism Drosophila melanogaster epilepsy gamma-aminobutyric acid (GABA) GABA transporter 1 intellectual disability
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.834498/full
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