Design, Synthesis, and Validation of a Novel [¹¹C]Promethazine PET Probe for Imaging Abeta Using Autoradiography

Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design an...

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Principais autores:	Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-04-01
coleção:	Molecules
Assuntos:	promethazine PET imaging Abeta Alzheimer autoradiography
Acesso em linha:	https://www.mdpi.com/1420-3049/26/8/2182
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