S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?
We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1−/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and...
Gardado en:
| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis Group
2020-07-01
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| Series: | Molecular & Cellular Oncology |
| Assuntos: | |
| Acceso en liña: | http://dx.doi.org/10.1080/23723556.2020.1746131 |
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