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Small Hexokinase 1 Peptide against Toxic SOD1 G93A Mitochondrial Accumulation in ALS Rescues the ATP-Related Respiration

Mutations in Cu/Zn Superoxide Dismutase (SOD1) gene represent one of the most common causes of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder that specifically affects motor neurons (MNs). The dismutase-active SOD1 G93A mutant is responsible for the formation of toxic aggreg...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Andrea Magrì, Pierpaolo Risiglione, Antonella Caccamo, Beatrice Formicola, Marianna Flora Tomasello, Cristina Arrigoni, Stefania Zimbone, Francesca Guarino, Francesca Re, Angela Messina
Hōputu: Artigo
Reo:Inglês
I whakaputaina: MDPI AG 2021-08-01
Rangatū:Biomedicines
Ngā marau:
amyotrophic lateral sclerosis
SOD1
VDAC1
hexokinase
mitochondria
interfering peptide
Urunga tuihono:https://www.mdpi.com/2227-9059/9/8/948
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