Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Abstract Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could functi...

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Autores principales:	Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-12-01
Colección:	Respiratory Research
Materias:	Cystic fibrosis Inflammation Kalydeco Ivacaftor Tezacaftor Lumacaftor
Acceso en línea:	https://doi.org/10.1186/s12931-019-1214-8
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