The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2022-09-01
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| Colección: | Communications Biology |
| Acceso en línea: | https://doi.org/10.1038/s42003-022-03985-7 |
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