Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage

Summary: Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we investigated this question by using mouse embryonic fibroblasts with conditional Brd4 k...

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Hlavní autoři:	Tiyun Wu, Haitong Hou, Anup Dey, Mahesh Bachu, Xiongfong Chen, Jan Wisniewski, Fuki Kudoh, Chao Chen, Sakshi Chauhan, Hua Xiao, Richard Pan, Keiko Ozato
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-07-01
Edice:	iScience
Témata:	Natural sciences Biological sciences Biochemistry Cell biology Cancer
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589004224010198
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