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TIPRL Regulates Stemness and Survival in Lung Cancer Stem Cells through CaMKK2‐CaMK4‐CREB Feedback Loop Activation

Abstract Frequent recurrence and metastasis caused by cancer stem cells (CSCs) are major challenges in lung cancer treatment. Therefore, identifying and characterizing specific CSC targets are crucial for the success of prospective targeted therapies. In this study, it is found that upregulated TOR...

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Main Authors: In‐Sung Song, Yu‐Jeong Jeong, Jae Kwang Yun, Jimin Lee, Hae‐Jun Yang, Young‐Ho Park, Sun‐Uk Kim, Seung‐Mo Hong, Peter C.W. Lee, Geun Dong Lee, Sung‐Wuk Jang
Format: Artigo
Language:Inglês
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
CaMKK2‐CaMK4‐CREB feedback loop activation
cancer stem cell
drug resistance
lung cancer
metastasis
TIPRL
Online Access:https://doi.org/10.1002/advs.202406309
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