Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway

The mammalian target of rapamycin (mTOR)-sterol regulatory element-binding proteins (SREBPs) signaling promotes lipogenesis. However, mTOR inhibitors also displayed a significant side effect of hyperlipidemia. Thus, it is essential to develop mTOR-specific inhibitors to inhibit lipogenesis. Here, we...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ping-Ting Xiao, Zhi-Shen Xie, Yu-Jia Kuang, Shi-Yu Liu, Chun Zeng, Ping Li, E-Hu Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-11-01
coleção:	Acta Pharmaceutica Sinica B
Assuntos:	FKBP38 Hyperlipidemia 3,5,6,7,8,3ʹ,4ʹ-heptamethoxyflavone mTOR SREBP
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383521001039
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!