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Intratumoral heterogeneity drives acquired therapy resistance in a patient with metastatic prostate cancer

Abstract Metastatic prostate cancer (PCa) is not curable due to its ability to acquire therapy resistance. Theoretically, acquired therapy resistance can be driven by changes to previously sensitive cancer cells or their environment and/or by outgrowth of a subpopulation of cancer cells with primary...

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Váldodahkkit: Dena P. Rhinehart, Jiaying Lai, David E. Sanin, Varsha Vakkala, Adrianna Mendes, Christopher Bailey, Emmanuel S. Antonarakis, Channing J. Paller, Xiaojun Wu, Tamara L. Lotan, Rachel Karchin, Laura A. Sena
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2024-12-01
Ráidu:npj Precision Oncology
Liŋkkat:https://doi.org/10.1038/s41698-024-00773-w
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