Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting toxicity of cancer treatment, yet reliable biomarkers to predict individual susceptibility remain lacking. Germline genetic variation has been widely investigated as a potential contributor to CIPN risk; however, the consis...

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Detalhes bibliográficos

Principais autores:	Aditya Maganti, Ishara Rankothge, Hunter Sakadales, Ethan Kok, James Britton, Neil Rao, Svetlana Shatunova, Katherine Shimell, Paula Manuela Rojas Zambrano, Susanna B. Park, Daniel Schweitzer, E-Liisa Laakso, Loic Yengo, Irina Vetter, Hana Starobova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	biomarkers chemotherapy-induced peripheral neuropathy (CIPN) genetic polymorphisms GWAS neurotoxicity pharmacogenomics
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1842379/full
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