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Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

Abstract Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of these tauopathies, tau spreads throughout the brain via synaptically-connected pathways. Such propagation of pathology is thought to be mediat...

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Main Authors: Malcolm Roberts, Ioanna Sevastou, Yoichi Imaizumi, Kavita Mistry, Sonia Talma, Madhurima Dey, Jane Gartlon, Hiroshi Ochiai, Zhi Zhou, Shigeru Akasofu, Naoki Tokuhara, Makoto Ogo, Muneo Aoyama, Hirofumi Aoyagi, Kate Strand, Ezat Sajedi, Kishan Lal Agarwala, Jared Spidel, Earl Albone, Kanta Horie, James M. Staddon, Rohan de Silva
Format: Artigo
Language:Inglês
Published: BMC 2020-02-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Alzheimer
tauopathy
immunotherapy
neurodegeneration
Online Access:https://doi.org/10.1186/s40478-020-0884-2
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