Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality

This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH. Many factors affecting the quality of the me...

Descripció completa

Dades bibliogràfiques

Autors principals:	Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák
Format:	Artigo
Idioma:	Inglês
Publicat:	International Association of Physical Chemists (IAPC) 2016-06-01
Col·lecció:	ADMET and DMPK
Matèries:	shake-flask solubility intrinsic solubility water solubility buffer solubility thermodynamic solubility Bjerrum curve CheqSol Potentiometric Cycling for Polymorph Creation Henderson-Hasselbalch equation aggregates oligomers micelles hydrates
Accés en línia:	http://pub.iapchem.org/ojs/index.php/admet/article/view/292
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!