WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer
Abstract Background Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC)...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2019-07-01
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| Seri Bilgileri: | Cell Communication and Signaling |
| Konular: | |
| Online Erişim: | http://link.springer.com/article/10.1186/s12964-019-0403-x |
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