Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction

Abstract Survivors of breast cancer face a substantially increased risk of developing contralateral breast cancer (CBC). We assessed whether risk prediction models for CBC are improved by integrating mammographic density (MD) and polygenic risk scores (PRS). We analyzed data from 399 European-ancest...

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Egile Nagusiak:	Elnaz Naderi, Gordon P. Watt, Julia A. Knight, Kathleen E. Malone, Charles F. Lynch, Esther M. John, Xiang Shu, Tuong L. Nguyen, Jung Hun Oh, Meghan Woods, Xiaolin Liang, Andriy Derkach, Malcolm C. Pike, Jonine L. Bernstein
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2026-03-01
Saila:	Scientific Reports
Gaiak:	Polygenic risk score Mammographic density Contralateral breast cancer Breast cancer survivors Risk prediction
Sarrera elektronikoa:	https://doi.org/10.1038/s41598-026-42365-7
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