Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis

IntroductionDysregulated T cell homeostasis leading to enhanced immune responses is a critical pathogenic mechanism in rheumatoid arthritis (RA). Programmed cell death protein 1 (PD-1) is a crucial immune checkpoint that modulates T cell activity. Soluble PD-1 (sPD-1) may contribute to the sustained...

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Autores principales:	Chao Yang, Miao Ma, Kangjie Yu, Yi Wang, Yuting Zhang, Yan Shen, Jun Wang, Xiaoke Wang, Lulu Luo, Ya Zhao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-12-01
Colección:	Frontiers in Immunology
Materias:	rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) soluble PD-1 MMP-9 PD-L1-MSA
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1665078/full
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