Probing the role of the C2F domain of otoferlin
Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause human auditory synaptopathy. We employed site-directed mutagenesis in mice to investigate the role of Ca2+ binding to the C2F domain o...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2023-12-01
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| Serie: | Frontiers in Molecular Neuroscience |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1299509/full |
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