Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction

Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Comp...

Ful tanımlama

Detaylı Bibliyografya

Asıl Yazarlar:	Tarek S. Ibrahim, Amr H. Moustafa, Ahmad J. Almalki, Rasha M. Allam, Abdulhamid Althagafi, Shadab Md, Mamdouh F. A. Mohamed
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis Group 2021-01-01
Seri Bilgileri:	Journal of Enzyme Inhibition and Medicinal Chemistry
Konular:	chalcone carboximidamide inos inhibitors anti-inflammatory amidoxime pge2
Online Erişim:	http://dx.doi.org/10.1080/14756366.2021.1929201
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!