Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters

Abstract Background The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an ‘open’ local chromatin configuration has long been known. However, the 3D topography of TREs within the nuclear landscape of individual cells in relation to their acti...

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Hlavní autoři:	Marion Cremer, Volker J. Schmid, Felix Kraus, Yolanda Markaki, Ines Hellmann, Andreas Maiser, Heinrich Leonhardt, Sam John, John Stamatoyannopoulos, Thomas Cremer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2017-08-01
Edice:	Epigenetics & Chromatin
Témata:	Transcription regulatory sequences DNAse I hypersensitive sites Super-resolution microscopy Chromatin domain Nuclear architecture Active and inactive nuclear compartment
On-line přístup:	http://link.springer.com/article/10.1186/s13072-017-0146-0
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