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Pathway-targeted pharmacogenomics of CYP1A2 in human liver

The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine. CYP1A2 activity is interindividually hi...

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Principais autores: Kathrin eKlein, Stefan eWinter, Miia eTurpeinen, Matthias eSchwab, Ulrich M Zanger
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2010-11-01
Serier:Frontiers in Pharmacology
Fag:
Pharmacogenetics
pharmacogenomics
SNP
cytochrome P450
multivariate analysis
candidate gene
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00129/full
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