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PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development

Objective: Preeclampsia (PE) is an idiopathic and life-threatening pregnancy-related disease. Alterations to DNA methylation in imprinted genes may play a crucial role in the dysfunction of trophoblast cells and PE. Materials and methods: Herein, we sought to elucidate the characteristics of PHLDA2...

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Autori principali: Jie Chen, Youhong Zheng, Lilin Hang, Huiyan Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-07-01
Serie:Taiwanese Journal of Obstetrics & Gynecology
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Accesso online:http://www.sciencedirect.com/science/article/pii/S1028455925001329
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