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Buddlejasaponin IV inhibits proliferation and migration via STAT3 suppression in gefitinib-resistant non-small cell lung cancer cells

Abstract Background Lung cancer is a leading cause of death globally, with non-small-cell lung cancer (NSCLC) often developing resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). This study explored the efficacy and mechanism of Buddlejasaponin IV (BJS IV) from Cli...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sung Chul Jang, Donghwa Kim, Jaeho Han, Dong Hyun Moon, Eun Seo Bae, Chae Won Ock, Hyen Joo Park, Sang Kook Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-02-01
Schriftenreihe:BMC Complementary Medicine and Therapies
Schlagworte:
Clinopodium chinense var. shibetchense
Buddlejasaponin IV
Antiproliferative activity
NSCLC
STAT3
Online-Zugang:https://doi.org/10.1186/s12906-026-05294-6
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