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The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity

Ferroptosis, a regulated form of cell death characterized by lipid peroxidation and iron accumulation, is increasingly recognized for its role in disease pathogenesis. The unfolded protein response (UPR) has been implicated in both endoplasmic reticulum (ER) stress and ferroptosis-mediated cell fate...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Thu-Hang Thi Nghiem, Kim Anh Nguyen, Fedho Kusuma, Soyoung Park, Jeongmin Park, Yeonsoo Joe, Jaeseok Han, Hun Taeg Chung
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-03-01
Schriftenreihe:Antioxidants
Schlagworte:
ER stress
ferroptosis
PERK
DDIT4
GPX4
unfolded protein response
Online-Zugang:https://www.mdpi.com/2076-3921/14/3/307
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