Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

Neuronal apoptosis plays key roles in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first reported the role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in alleviating secondary brain injury through anti-apoptosis in rat model of ICH. The recombinant hu...

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Autors principals:	Weilin Xu, Liansheng Gao, Tao Li, Jingwei Zheng, Anwen Shao, Jianmin Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-05-01
Col·lecció:	Frontiers in Molecular Neuroscience
Matèries:	mesencephalic astrocyte-derived neurotrophic factor (MANF) intracerebral hemorrhage neuronal apoptosis secondary brain injury neuroprotection
Accés en línia:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00176/full
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