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LRP8 Promotes colorectal cancer progression by suppressing ferroptosis through the SLC3A2/GPX4 signalling axis

Abstract Background Colorectal cancer (CRC) persists as one of the most lethal malignancies worldwide, with therapeutic resistance representing a significant obstacle in clinical management. Ferroptosis, a form of programmed cell death triggered by iron accumulation and lipid peroxidation, has recen...

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Kaydedildi:
Asıl Yazarlar: Chengzhang Zhu, Zhengpeng Qian, Shijie Yang, Yongfeng Wang, Xiongfei Yang, Binbin Du, Hui Cai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2026-02-01
Seri Bilgileri:European Journal of Medical Research
Konular:
LRP8
Colorectal cancer
Ferroptosis
SLC3A2
GPX4
Iron metabolism
Online Erişim:https://doi.org/10.1186/s40001-026-03964-2
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