Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.

The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated α-subunits HIF-1α or HIF-2α. Both are regulated by oxygen dependent degradatio...

Полное описание

Библиографические подробности

Главные авторы:	Ruth E Schietke, Thomas Hackenbeck, Maxine Tran, Regina Günther, Bernd Klanke, Christina L Warnecke, Karl X Knaup, Deepa Shukla, Christian Rosenberger, Robert Koesters, Sebastian Bachmann, Peter Betz, Gunnar Schley, Johannes Schödel, Carsten Willam, Thomas Winkler, Kerstin Amann, Kai-Uwe Eckardt, Patrick Maxwell, Michael S Wiesener
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2012-01-01
Серии:	PLoS ONE
Online-ссылка:	https://doi.org/10.1371/journal.pone.0031034
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