Molecular and biophysical remodeling of the blood–brain barrier in glioblastoma: mechanistic drivers of tumor–neurovascular crosstalk

Glioblastoma (GBM) resists conventional treatment in large part because the blood–brain barrier (BBB) and its tumor-modified counterpart, the blood–tumor barrier (BTB), form a spatially heterogeneous, actively regulated interface that governs transport. In this setting, permeability, perfusion, and...

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Hlavní autoři:	Matthew Abikenari, Matthew Adam Sjoholm, Justin Liu, George Nageeb, Joseph H. Ha, Janet Wu, Alexander Ren, Jamasb Sayadi, Jaejoon Lim, Kwang Bog Cho, Rohit Verma, Ravi Medikonda, Matei Banu, Michael Lim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-12-01
Edice:	Frontiers in Physics
Témata:	glioblastoma blood–brain barrier blood–tumor barrier drug delivery focused ultrasound immunotherapy
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphy.2025.1723329/full
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