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Innovative nanoparticle-based approach for preeclampsia treatment through inhibition of KAT7-mediated histone modifications

Preeclampsia (PE) is a serious pregnancy-related disorder characterized by dysregulated glycolysis and aberrant histone lactylation in the placenta. In this study, we developed folic acid (FA)-modified lipid nanoparticles (FA-LNPs) encapsulating small interfering RNA targeting pyruvate kinase M (si-...

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Huvudupphov: Xiaojun Zhu, Weidong Fei, Yusi Wang, Min Si, Yao Yao, Xiujun Han, Xiaohan Guo, Zhi Li, Peiyue Jiang
Materialtyp: Artigo
Språk:Inglês
Utgiven: Tsinghua University Press 2025-08-01
Serie:Nano Research
Ämnen:
preeclampsia
glycolytic metabolism
lactylation
pyruvate kinase m
kat7
Länkar:https://www.sciopen.com/article/10.26599/NR.2025.94907706
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