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Soluble markers of B cell activation suggest a role of B cells in the pathogenesis of systemic sclerosis-associated pulmonary arterial hypertension

IntroductionSoluble markers of B cell activation are interesting diagnostic and prognostic tools in autoimmune diseases. Data in systemic sclerosis (SSc) are scarce and few studies focused on their association with disease characteristics.Methods1. Serum levels of 14 B cell biomarkers (β2-microglobu...

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Main Authors: Sébastien Sanges, Thomas Guerrier, Alain Duhamel, Lucile Guilbert, Carine Hauspie, Alexis Largy, Maïté Balden, Céline Podevin, Guillaume Lefèvre, Manel Jendoubi, Silvia Speca, Éric Hachulla, Vincent Sobanski, Sylvain Dubucquoi, David Launay
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
pulmonary arterial hypertension
B cell
humoral immunity
angiogenesis
pro-angiogenic factors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.954007/full
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