Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1
DNA methyltransferase 1 (DNMT1) is the enzyme primarily responsible for propagation of the methylation pattern in cells. Mutations in DNMT1 have been linked to the development of adult-onset neurodegenerative disorders; these disease-associated mutations occur in the regulatory replication foci-targ...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI AG
2023-07-01
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| Serie: | DNA |
| Soggetti: | |
| Accesso online: | https://www.mdpi.com/2673-8856/3/3/10 |
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