Structural Insights into the Interactions of Digoxin and Na⁺/K⁺-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

Digoxin is a cardiac glycoside long used to treat congestive heart failure and found recently to show antitumor potential. The hydroxy groups connected at the C-12, C-14, and C-3′a positions; the C-17 unsaturated lactone unit; the conformation of the steroid core; and the C-3 saccharide moiety have...

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Principais autores:	Yulin Ren, Sijin Wu, Joanna E. Burdette, Xiaolin Cheng, A. Douglas Kinghorn
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-06-01
Serija:	Molecules
Teme:	digoxin cytotoxicity Na<sup>+</sup>/K<sup>+</sup>-ATPase docking profiles molecular targets
Online dostop:	https://www.mdpi.com/1420-3049/26/12/3672
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