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Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice

Abstract Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown. We aimed to elucidate the mechanism of action of propofol in the LC-NA neurons. LC-N...

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Váldodahkkit: Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2025-10-01
Ráidu:Scientific Reports
Fáttát:
Liŋkkat:https://doi.org/10.1038/s41598-025-22005-2
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