SeSA-HCPT: A dual-targeting agent that induces DNA damage and inhibits repair for castration-resistant prostate cancer therapy

Summary: Castration-resistant prostate cancer (CRPC) remains difficult to treat due to tumor heterogeneity and resistance. We developed SeSA-HCPT, a dual-targeting compound that links the topoisomerase I inhibitor hydroxycamptothecin (HCPT) with a selenium analog of the histone deacetylase (HDAC) in...

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Bibliografische Detailangaben

Hauptverfasser:	Yajie Wang, Qiuyu Wang, Li Meng, Xiaoying Lian, Xinyue Wu, Yuqing Wang, Tianyu Zhang, ShiLin Wei, Yanming Wang, Changjun Zhu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-02-01
Schriftenreihe:	iScience
Schlagworte:	Molecular biology Biotechnology Cancer
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004226001999
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